Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
نویسندگان
چکیده
BACKGROUND Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. METHOD Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38-39, 40, 41, 42, 43, 44, 45, 46, and 47-54. RESULTS Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. DISCUSSION Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2011